32.6 years, P < 0.001) and more often Caucasian (75% vs. Patients with ORG were older (mean 42.9 vs. Seventy-one patients with ORG were compared to 50 patients with idiopathic FSGS (I-FSGS). Indications for renal biopsy included proteinuria (N = 40) or proteinuria and renal insufficiency (N = 31). Review of 6818 native renal biopsies received from 1986 to 2000 revealed a progressive increase in biopsy incidence of ORG from 0.2% in 1986-1990 to 2.0% in 1996-2000 (P = 0.0001). Obesity-related glomerulopathy (ORG) was defined morphologically as focal segmental glomerulosclerosis and glomerulomegaly (O-FSGS N = 57) or glomerulomegaly alone (O-GM N = 14). Obesity was defined as body mass index (BMI)> 30 kg/m2. We report the first large renal biopsy-based clinicopathologic study on obesity-related glomerulopathy.
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